Simultaneous Analysis of Oral Antidiabetic Drug by LC-MS/MS
نویسندگان
چکیده
منابع مشابه
drug transport mechanism of oral antidiabetic nanomedicines
context: over the last few decades, extensive efforts have been made worldwide to develop nanomedicine delivery systems, especially via oral route for antidiabetic drugs. absorption of insulin is hindered by epithelial cells of gastrointestinal tract, acidic gastric ph and digestive enzymes. evidence acquisition: recent reports have identified and explained the beneficial role of several struct...
متن کاملDrug Transport Mechanism of Oral Antidiabetic Nanomedicines
CONTEXT Over the last few decades, extensive efforts have been made worldwide to develop nanomedicine delivery systems, especially via oral route for antidiabetic drugs. Absorption of insulin is hindered by epithelial cells of gastrointestinal tract, acidic gastric pH and digestive enzymes. EVIDENCE ACQUISITION Recent reports have identified and explained the beneficial role of several struct...
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Uptake transporters (e.g., members of the SLC superfamily of solute carriers) and export proteins (e.g., members of the ABC transporter superfamily) are important determinants for the pharmacokinetics of drugs. Alterations of drug transport due to concomitantly administered drugs that interfere with drug transport may alter the kinetics of drug substrates. In vitro and in vivo studies indicate ...
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Counterfeiting in the pharmaceutical industry has become a serious and underreported problem, particularly in developing countries. This Application Note shows the analysis of antidiabetic drugs of the sulfonylurea class using the Agilent 1220 Infinity Gradient LC system with diode array detector (DAD). Both HPLC and UHPLC methods revealed excellent precision, accuracy and linearity as well as ...
متن کاملOral Antidiabetic Sulfonamides
In October 1955 three reports in the Deutsche Medizinische Wochenschrift' described a new sulfonamide derivative possessing the ability when given by mouth to reduce normal blood sugar values to subnormal, and elevated blood and urine sugar values in diabetes to normal. Reduction of normoglycemia had been shown with other sulfonamide derivatives as early as 1942," but the application to therapy...
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ژورنال
عنوان ژورنال: CHROMATOGRAPHY
سال: 2015
ISSN: 1342-8284,1348-3315
DOI: 10.15583/jpchrom.2015.003